The final proposed system of RBC vasodilation in the presence of nitrite would be the reduction of nitrite to NO by Hb. Brooks very first studied the nitrite Hb conversation in 1937 which get the job done was later prolonged by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to form metHb and NO (Brooks, 1937;